On data randomized crossover study at 12 healthy volunteers, at application generic for nexium on 40 mg it is daily throughout 5 days area under crooked dependences "concentration-time" (Auc) exceeded that on 70 % at application of omeprazole on 20 mg throughout like period . On-visible, this is connected from themes, what is subjected by generic for nexium smaller extent to hydroxylation with participation of cytochrome P450 (Cyp2c19) in liver and small ground clearance has than R-isomer of omeprazole. So, generic Axagon is had by low ground clearance than omeprazole, S consisting from mix and R isomers. It is necessary to note that this property is basic distinguishes generic Sompraz from all existing blockers of proton pump. There exists polymorphism of gene CYP2C19 in a population, and only at 2-5 % of representatives of race structure of a gene and, accordingly, cytochrome P450 "Is favorable" for metabolism of inhibitors of proton pump. Other it is rather fast and they metabolize them in different degree, what does not allow with big accuracy to predict efficiency of blockers of proton pump and cause presence of persons, steady to these preparations. This will concern to all blockers of proton pump, including generic nexium. And only creation of generic for nexium lets to overcome given lack. In this connection it is not surprising that average values Auc on fifth day reception generic Zoleri in daily dose 40 and 20 mg were in 5 and 2 times been higher than at reception of omeprazole in doze 20 mg / day. In double blind research at 36 they made patients 12, 6, 4, 2 and 2, 3 mcmole / l-h (p <0, 0001). Absolute bioavailability and Auc generic Lucen they are increased in current of first week of reception preparation. So , bioavailability increased from 50 to 68 % from first on fifth day reception of generic for nexium in dose 20 mg / day and from 64 to 89 % at its application in doze of 40 mg / day. Values of Auc increased from 1, 34 to 2, 55 mcmole / l-h and from 4, 32 to 11, 21 mcmole / l-h accordingly. Auc Esopral realistically correlated with share of time, throughout which pH exceeded in stomach 4, and allows well to predict suppression of gastric secretion than maximal concentration of preparation in blood serum. Pharmacokinetics preparation was studied also at elderly patients. Auc and maximum concentration realistically did not differ at 13 healthy elderly volunteers (in age from 71 to 80 years) and 39 sick by generic nexium (in age from 29 to 58 years), 40 mg accepting generic for nexium in doze throughout 5 days. On fifth day of reception of Nexiam Auc and maximal concentration of preparation in blood at elderly volunteers made 15, 98 mcmole / l-h and 5, 57 mcmole / l accordingly. Light and moderate infringement of function of liver at sick cirrhosis livers (on classification I) it did not influence on Auc and period of semiejection of generic for nexium in dose of 40 mg / day. However at sick with heavy infringements of liver function these parameters increased on 76 and 29 % is respective in contrast with those at healthy volunteers or sick by nexium. In the same time of infringement liver functions did not render influence on maximal to concentration of preparation in plasma.

On data double blind crossover study at 36 sick with symptoms of GERB , application of nexium generic in doze 20 and 40 mg / day throughout 5 days intraventricular value supported pH> 4 more long time than application of omeprazole in dose of 20 mg / day (rice. 1). On fifth day mean value pH it also buy nexium for 24 h at treatment in both doses highly than at use of omeprazole (4, 1 and 4, 9 against 3, 6; p <0, 01 and p <0, 001 accordingly). Adding patients , at which value pH in stomach were> 4 on extent more 12 or 16 h in groups generic drug for nexium 20 (54 and 24 % pursuant to) and 40 mg (92 and 56 %), was higher than in group of omeprazole (44 and 14 %, p <0, 0001). It is important to remind that given parameter correlates with rates of healing of erosive-ulcer defeats of mucous environment of gullet and stomach. In research at 115 patients from GERB it also was shown that daily reception of generic for nexium is supported in dose of 40 mg by intraventricular value pH> 4 in current of more long time daily than therapy omeprazole in dose of 40 mg. Share of day, throughout which pH exceeded 4, made two preparations in first day of reception 48, 6 and 40, 6 % (p <0, 001) accordingly, and on fifth day- 68, 4 and 62, 0 % (rice. 1). On fifth day intraventricular value pH it was kept highly 4 more than 12 h at 88 and 77 % of patients, accepting generic for nexium and omeprazole accordingly.